Frank "The Irishman" Sheeran is a man with a lot on his mind. The former labor union high official and hitman, learned to kill serving in Italy during the Second World War. He now looks back on his life and the hits that defined his mob career, maintaining connections with the Bufalino crime family. In particular, the part he claims to have played in the disappearance of his life-long friend, Jimmy Hoffa, the former president of the International Brotherhood of Teamsters, who mysteriously vanished in late July 1975 at the age of 62.